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Patterns of α- and β-catenin and E-cadherin expression in colorectal adenomas and carcinomas

✍ Scribed by Van Der Wurff, Anna A. M.; Vermeulen, Stefan J. T.; Van Der Linden, Edith P. M.; Mareel, Marc M.; Bosman, Fred T.; Arends, Jan-Willem

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
245 KB
Volume
182
Category
Article
ISSN
0022-3417

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✦ Synopsis

Previous in vitro and in vivo model studies have shown that when E-cadherin expression in carcinoma cells is reduced, invasive behaviour ensues. The situation in human cancer in vivo, however, appears to be more complex, as immunohistochemically determined E-cadherin expression in various carcinomas, including colorectal cancer, does not always correlate with invasive growth. Loss of cell adhesion during invasion in spite of E-cadherin expression might be associated with a defective cadherin-catenin complex. The expression of -and -catenin in comparison with E-cadherin was therefore examined in colorectal adenomas and carcinomas and in lymph node and liver metastases. In normal colonic mucosa, -and -catenin immunoreactivity occurred along the lateral plasma membranes of the epithelial cells, in a pattern identical to E-cadherin staining. A similar pattern was found in colorectal adenomas and in most malignancies. In general, in neoplastic epithelia, the majority of the cancer cells displayed a normal (matching) pattern of E-cadherin and catenin expression. It is concluded that the patterns of expression of E-cadherin and -and -catenin are very similar in colorectal neoplasms. This observation indicates that invasion in colorectal cancer is not paralleled by consistent loss of expression of the components of the cadherin-catenin complex. 1997 by John Wiley & Sons, Ltd.

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