Cerebral gene expression profiles in sporadic Creutzfeldt–Jakob disease
✍ Scribed by Wei Xiang; Otto Windl; Ingo M. Westner; Manuela Neumann; Inga Zerr; Rosa M. Lederer; Hans A. Kretzschmar
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 439 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0364-5134
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The polymorphism at codon 219 of the prion protein gene (PRNP) was found in the general Japanese population with 6% allele frequency. Herein, we examined 85 cases of sporadic Creutzfeldt-Jakob disease (CJD) for the codon 219 polymorphism. The codon 219G'"'Ly" heterozygous polymorphism was not found
Creutzfeldt-Jakob disease (CJD) belongs to a group of chronic, progressive, neurodegenerative disorders that may be hereditary, infectious, or sporadic. Hereditary CJDs are associated with mutations in the PRNP gene on chromosome 20p12-pter. We report a family in which four patients developed classi