Codon 219 lys allele of PRNP is not found in sporadic Creutzfeldt-Jakob disease
✍ Scribed by Satoshi Shibuya; June Higuchi; Ryong-Woon Shin; June Tateishi; Dr Tetsuyuki Kitamoto
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 455 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
✦ Synopsis
The polymorphism at codon 219 of the prion protein gene (PRNP) was found in the general Japanese population with 6% allele frequency. Herein, we examined 85 cases of sporadic Creutzfeldt-Jakob disease (CJD) for the codon 219 polymorphism. The codon 219G'"'Ly" heterozygous polymorphism was not found in these CJD cases. In addition, we examined 43 patients with dementia of non-CJD origin, and 4 were found to have the codon 219G1dLy* heterozygous polymorphism with a similar allele frequency as in the general population. Thus, the codon 219G'"'LF heterozygous polymorphism might be uniquely excluded from sporadic CJD.