𝔖 Bobbio Scriptorium
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Mathematical analysis of a basic model for epidermal wound healing

✍ Scribed by J. A. Sherratt; J. D. Murray

Publisher
Springer
Year
1991
Tongue
English
Weight
847 KB
Volume
29
Category
Article
ISSN
0303-6812

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✦ Synopsis

The stimuli for the increase in epidermal mitosis during wound healing are not fully known. We construct a mathematical model which suggests that biochemical regulation of mitosis is fundamental to the process, and that a single chemical with a simple regulatory effect can account for the healing of circular epidermal wounds. The numerical results of the model compare well with experimental data. We investigate the model analytically by making biologically relevant approximations. We then obtain travelling wave solutions which provide information about the accuracy of these approximations and clarify the roles of the various model parameters.

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