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A mathematical model for insulin kinetics III. Sensitivity analysis of the model

โœ Scribed by C.P. Geevan; J. Subba Rao; Gita Subba Rao; J.S. Bajaj

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
367 KB
Volume
147
Category
Article
ISSN
0022-5193

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โœฆ Synopsis

A non-linear mathematical model involving four variables and several constants incorporating beta-cell kinetics, a glucose-insulin feedback system and a gastrointestinal absorption term had been applied in earlier papers to various forms of diabetes mellitus. In this paper, we examine the response of the system to variations in the parameters and to initial conditions using sensitivity analysis. It is found that such a method leads to results that are consistent with clinical findings. Further, it is suggested that such an analysis could help in making some predictions regarding future directions in the therapy of diabetes mellitus.

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