In this paper we study a model of necrotic tumor growth. The tumor comprises necrotic cells which occupy a radially symmetric core and life proliferating cells which occupy a radially symmetric shell adjacent to the core. The proliferating cells receive nutrients through diffusion from the outer bou
Analysis of a delayed mathematical model for tumor growth
โ Scribed by Shihe Xu
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 295 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1468-1218
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โฆ Synopsis
In this paper, a delayed mathematical model of a nonlinear reaction-diffusion equations modeling the growth of tumors is studied. The establishment of the model is based on the diffusion of nutrient and mass conservation for the two-process proliferation and apoptosis (cell death due to aging). It is assumed that the process of proliferation is delayed compared to apoptosis.
Nonnegativity of the solutions and stability of stationary solutions are studied in the paper. The results show that the dynamical behavior of the solutions of the model is similar to that of the solutions for the corresponding non-retarded problem under some assumptions.
๐ SIMILAR VOLUMES
The Gompertz equation has emerged as the most useful model for tumor growth analysis but lacks a demonstrable relationship between its parameters and biological growth regulatory mechanisms. A new model for tumor growth analysis is developed based upon a class of mechanisms considered most likely to