✦ LIBER ✦

Maternal urine hyperglycosylated hCG in pregnancies with Down syndrome

✍ Scribed by H. S. Cuckle; S. Shahabi; I. K. Sehmi; R. Jones; L. A. Cole

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 116 KB
Volume: 19
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199910)19:10<918::aid-pd680>3.0.co;2-4

No coin nor oath required. For personal study only.

✦ Synopsis

Stored maternal urine samples were used to determine the distribution of hyperglycosylated human chorionic gonadotrophin (H-hCG) levels in pregnancies with Down syndrome. A total of 349 samples from singleton pregnancies, including 45 with Down syndrome, were tested at 10-19 weeks' gestation. Urinary concentration was allowed for by expressing H-hCG in ng per mmol creatinine. The median level in Down syndrome was 3.63 multiples of the gestation-specific median in unaffected pregnancies (p<0.0001, Wilcoxon rank-sum test, two-tail). However, creatinine levels were relatively low in cases and creatinine did not fully correct for concentration. When this bias was allowed for, the median level was 3.34 multiples of the normal median (MoM). The H-hCG elevation in affected pregnancies was more marked at 14 weeks' gestation or later: a median of 4.64 MoM and allowing for creatinine bias 4.46 MoM.

📜 SIMILAR VOLUMES

Hyperglycosylated hcg, a potential alter

Hyperglycosylated hcg, a potential alternative to hcg in Down syndrome screening

✍ Laurence A. Cole; Aziza Omrani; Dilek Cermik; Ray O. Bahado Singh; Maurice J. Ma 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 179 KB 👁 1 views

Hyperglycosylated hCG (H-hCG) is a minor variant of hCG with abnormal oligosaccharide side chains. It is the principal gonadotropin detected in the serum and urine of patients with gestational choriocarcinoma. A monoclonal antibody was produced against this antigen and an immunoassay developed. Leve

Measures of urine concentration in mater

Measures of urine concentration in maternal urine screening for Down syndrome

✍ R. K. Iles; A. Black; L. K. Gunn; I. K. Sehmi; H. S. Cuckle; T. Chard 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 1 views

A study was carried out to assess eight methods of normalizing the level of urinary beta-core human chorionic gonadotropin (hCG) for variable urine concentration. We compared the standard approach--creatinine determination by the Jaffe method--with high performance liquid chromatography (HPLC) measu

Maternal serum hCG and SP1 in pregnancie

Maternal serum hCG and SP1 in pregnancies with fetal aneuploidy

✍ Bartels, Iris ;Thiele, Marion ;Bogart, Mark H. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 384 KB

Screening for Down syndrome using urine

Screening for Down syndrome using urine hCG free β-subunit in the second trimester of pregnancy

✍ Laurence A. Cole; Melissa Jacobs; Taichi Isozaki; Glenn E. Palomaki; Ray O. Baha 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 53 KB 👁 1 views

Human chorionic gonadotropin (hCG) free beta-subunit levels were determined in 709 control and 13 Down syndrome urine samples from the second trimester of pregnancy. Results were normalized to urine creatinine concentration and converted to multiples of the unaffected pregnancy medium (MOM). The con

Down's syndrome and maternal smoking in

Down's syndrome and maternal smoking in early pregnancy

✍ Karin Källén 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 31 KB 👁 1 views

Several previous studies have suggested that maternal smoking is associated with a decreased incidence of trisomy 21. By using the Swedish health registries, 1,321 infants with Down's syndrome (DS) were selected among 1,117,021 infants born in 1983-1993 with known smoking exposure in early pregnancy

Maternal serum activin A and follistatin

Maternal serum activin A and follistatin levels in pregnancies with Down syndrome

✍ H. S. Cuckle; I. Sehmi; R. Jones; L. W. Evans 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 152 KB 👁 1 views

Inhibin A is now an established second-trimester maternal serum marker of Down syndrome. Since activin A has a common -subunit to inhibin A we evaluated this substance and its binding protein, follistatin, as potential markers. We studied 30 affected and 199 unaffected pregnancies at 13-16 weeks' ge