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Maternal serum activin A and follistatin levels in pregnancies with Down syndrome

✍ Scribed by H. S. Cuckle; I. Sehmi; R. Jones; L. W. Evans

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
152 KB
Volume
19
Category
Article
ISSN
0197-3851

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✦ Synopsis

Inhibin A is now an established second-trimester maternal serum marker of Down syndrome. Since activin A has a common -subunit to inhibin A we evaluated this substance and its binding protein, follistatin, as potential markers. We studied 30 affected and 199 unaffected pregnancies at 13-16 weeks' gestation. There was a statistically significant increase in activin A level among the cases with 8 (27 per cent) exceeding the 90th centile in the controls, and 6 (20 per cent) above the 95th centile. However, the extent of overlap was too great to be of value in screening. There was a small decrease in follistatin levels among cases but it did not reach statistical significance.

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