𝔖 Bobbio Scriptorium
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Maternal serum alpha-fetoprotein levels in congenital nephrotic syndrome carrier pregnancies

✍ Scribed by M. Carrera; M. Kestilä; C. de la Iglesia; J. Ruiz; B. Serra; R. Baraibar

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
110 KB
Volume
19
Category
Article
ISSN
0197-3851

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✦ Synopsis

correctly normalize urine data. The tighter distribution of hyperglycosylated hCG measurements in serum may compensate for the lesser elevation of values in Down syndrome cases. Hyperglycosylated hCG determinations might be equally useful in urine and serum samples. 60 per cent sensitivity is suggested with as little as 1.5 per cent false-positive rate. It might be possible to combine serum hyperglycosylated hCG with established serum markers to achieve higher detection rates. Hyperglycosylated hCG measurements could, for instance, replace or supplement regular hCG in the serum triple-screen test. Larger studies are now needed to confirm these preliminary observations.

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