✦ LIBER ✦

Measures of urine concentration in maternal urine screening for Down syndrome

✍ Scribed by R. K. Iles; A. Black; L. K. Gunn; I. K. Sehmi; H. S. Cuckle; T. Chard

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 124 KB
Volume: 18
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(1998100)18:10<1006::aid-pd386>3.0.co;2-o

No coin nor oath required. For personal study only.

✦ Synopsis

A study was carried out to assess eight methods of normalizing the level of urinary beta-core human chorionic gonadotropin (hCG) for variable urine concentration. We compared the standard approach--creatinine determination by the Jaffe method--with high performance liquid chromatography (HPLC) measurement of creatinine, osmolarity and optical density at five wavelengths. Urine samples were included from a total of 472 women with unaffected singleton pregnancies at 15 weeks' gestation. The median beta-core hCG value was determined for each decile group when the results were ranked in turn according to the different measures of urine concentration. Creatinine using the Jaffe method had a much stronger relationship with median beta-core hCG than the other measures. Linear regression across the decile groups gave an R2 value for Jaffe of 0.85 compared with HPLC of 0.53, osmolarity of 0.52, optical density at 405 nm of 0.72, at 450 nm of 0.57, at 490 nm of 0.33, at 570 nm of 0.34 and at 630 nm of 0.33. We conclude that when screening with urinary beta-core hCG measuring creatinine appears to be an adequate method of allowing for variable urine concentration.

📜 SIMILAR VOLUMES

Maternal urine hyperglycosylated hCG in

Maternal urine hyperglycosylated hCG in pregnancies with Down syndrome

✍ H. S. Cuckle; S. Shahabi; I. K. Sehmi; R. Jones; L. A. Cole 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 2 views

Stored maternal urine samples were used to determine the distribution of hyperglycosylated human chorionic gonadotrophin (H-hCG) levels in pregnancies with Down syndrome. A total of 349 samples from singleton pregnancies, including 45 with Down syndrome, were tested at 10-19 weeks' gestation. Urinar

Collaborative study of maternal urine β

Collaborative study of maternal urine β -core human chorionic gonadotrophin screening for Down syndrome

✍ Howard S. Cuckle; Jacob A. Canick; Leonard H. Kellner 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 183 KB 👁 1 views

Several studies have shown that second-trimester maternal urine -core human chorionic gonadotrophin (hCG) levels are raised on average in Down syndrome pregnancies. However, in all but one, testing was retrospective after extended sample storage and so we carried out a large international multicentr

New triple screen test for Down syndrome

New triple screen test for Down syndrome: Combined urine analytes and serum AFP

✍ Ray O. Bahado-Singh; Utku Oz; Ertug Kovanci; Dilek Cermik; Divinia Flores; Joshu 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 58 KB 👁 1 views

In this study we report a new triple test that combines serum AFP, urine ␤-core fragment of hCG, total urine estriol, and maternal age for calculating individual Down syndrome odds in the second trimester. The urine ␤-core fragment/estriol ratio was used as a single screening variable. Analyte level

Screening for Down syndrome using urine

Screening for Down syndrome using urine hCG free β-subunit in the second trimester of pregnancy

✍ Laurence A. Cole; Melissa Jacobs; Taichi Isozaki; Glenn E. Palomaki; Ray O. Baha 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 53 KB 👁 1 views

Human chorionic gonadotropin (hCG) free beta-subunit levels were determined in 709 control and 13 Down syndrome urine samples from the second trimester of pregnancy. Results were normalized to urine creatinine concentration and converted to multiples of the unaffected pregnancy medium (MOM). The con

Dehydrosteroid measurements in maternal

Dehydrosteroid measurements in maternal urine or serum for the prenatal diagnosis of Smith–Lemli–Opitz syndrome (SLOS)

✍ Cedric H.L. Shackleton; Josep Marcos; Glenn E. Palomaki; Wendy Y. Craig; Richard 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 127 KB 👁 1 views

## Abstract In a large multi‐center trial involving prenatal screening for Smith–Lemli–Opitz syndrome (SLOS), we evaluated maternal urine and serum steroid analysis as a non‐invasive diagnostic alternative to amniotic fluid sterol analysis. Candidate steroid ratios included: 7‐dehydropregnanetriol/

MATERNAL SERUM SCREENING FOR FETAL DOWN

MATERNAL SERUM SCREENING FOR FETAL DOWN SYNDROME IN IVF PREGNANCIES

✍ L. S. M. RIBBERT; L. H. KORNMAN; B. T. H. M. DE WOLF; A. H. M. SIMONS; C. A. M. 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB 👁 2 views

To assess the influence of in vitro fertilization (IVF) on maternal serum human chorionic gonadotrophin (hCG) and alpha-fetoprotein (AFP), the maternal serum hCG and AFP values were studied in 67 IVF pregnancies and compared with the results of a control group of 4732 spontaneously conceiving patien