✦ LIBER ✦

Mass spectrometry of various neuromuscular blocking agents

✍ Scribed by Timothy R. Baker; Paul Vouros; Jeevendra A. J. Martyn

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 214 KB
Volume: 25
Category: Article
ISSN: 1076-5174
DOI: 10.1002/oms.1210250211

No coin nor oath required. For personal study only.

✦ Synopsis

Neuromuscular blocking agents are utilized during surgical procedures in conjunction with general anesthetics. Previously we have reported on the use of the moving belt LC/MS interface for the mass spectral characterization of pancuronium bromide, vecuronium bromide, and their deacetylated metabolites [I]. An assay for the determination of these drugs in biological fluids has also been described [21. The applicability of these techniques for the determination of additional muscle relaxants pipecuronium, metocurine, and atracurium is demonstrated here.

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