Chemical lonization mass spectrometry of trimethylsilyl derivatives of various prostaglandins

✍ Scribed by Toshio Ariga; Minoru Suzuki; Ikuo Morita; Sei-itsu Murota; Tadashi Miyatake

• Publisher: Elsevier Science
• Year: 1978
• Tongue: English
• Weight: 441 KB
• Volume: 90
• Category: Article
• ISSN: 0003-2697
• DOI: 10.1016/0003-2697(78)90021-0

✦ Synopsis

Methoxime-trimethylsilyl

derivatives of prostaglandin A, B, and E series and trimethylsilyl derivatives of prostaglandin F series were investigated by gas chromatography-chemical ionization (CI) mass spectrometry. In ammonia CI mass spectrometry of both derivatives, the ion at m/e (M + l)+ or (M + 18)+ was recorded as the base peak. The syn and anti isomers of prostaglandin A and E series could be distinguished from each other by a characteristic ion, which was produced by the loss of trimethylsilanol from m/e (M + I)+. The (Y and p isomers of prostaglandin F series could also be discriminated from each other by comparing the intensities of the characteristic ions from sequential loss of trimethylsilanols from m/e (M + l)+ and (M + 18)+.