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Mass Spectrometric Profiling of Intact Biological Tissue by Using Desorption Electrospray Ionization

✍ Scribed by Justin M. Wiseman; Satu M. Puolitaival; Zoltán Takáts; R. Graham Cooks; Richard M. Caprioli


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
138 KB
Volume
44
Category
Article
ISSN
0044-8249

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Mass Spectrometric Profiling of Intact B
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Imaging mass spectrometry has emerged as a powerful technique based on time-of-flight secondary-ion mass spectrometry (TOF-SIMS) [1] and matrix-assisted laser desorption/ ionization (MALDI). [2,3] However, until now, the massspectrometric analysis of biological tissues has been limited to techniques

Titelbild: Mass Spectrometric Profiling
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**Die Desorptions‐Elektrospray‐Ionisierung** wird für die massenspektrometrische Analyse von Phospholipiden genutzt. In ihrer Zuschrift auf S. 7256 ff. beschreiben R. G. Cooks, R. M. Caprioli et al. die schnelle Analyse von unbehandelten biologischen Geweben, darunter der Tumorregion von Lebergewebe

Cover Picture: Mass Spectrometric Profil
✍ Justin M. Wiseman; Satu M. Puolitaival; Zoltán Takáts; R. Graham Cooks; Richard 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 67 KB

**Desorption electrospray ionization** is applied to the mass spectrometric profiling of phospholipids. In their Communication on page 7094 ff., R. G. Cooks, R. M. Caprioli, and co‐workers report the rapid analysis of untreated biological tissues, including the tumor region of liver tissue. The impa

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A method based on liquid chromatography (LC) combined with electrospray ionization tandem mass spectrometry for the analysis of the frequency of formation of 8-hydroxydeoxyguanosine (8OHdGuo), a biomarker of oxidative damage to DNA, has been developed. This analytical technique has the advantage ove