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Marquages par [14C] et [13C] de la N-(2-diéthylaminoéthyl)-4-iodobenzamide et de la N-(3-diméthylaminoprophyl)-4-iodobenzamide, traceurs du mélanome

✍ Scribed by M. F. Moreau; D. Parry; M. Bayle; J. Papon; P. Labarre; A. Veyre

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
468 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

N‐(2‐diethylaminoethyl)‐4‐iodobenzamide (I) and N‐(3‐dimethylaminopropyl)‐4‐iodobenzamide (II), recently developed in our laboratory, are promising agents for metastatic melanoma detection in nuclear medicine. In order to study their “in vivo” metabolism, we labelled them with carbon‐14 and carbon‐13 on two sites: on the carbonyl group (Ia, IIa), and on the dialkylaminoalkyl moiety (Ib, IIb). The overall yields calculated from sodium [^14^C] or [^13^C] cyanide used as precursor are in the range of 55% for Ia, IIa, IIb, and 21% for Ib.

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