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Marquage par 35S, 14C, 3H DE LA DI [(chloro-2 ethyl)-2 N-nitroso N- carbamoyl], N, N-cystamine OU cncc

✍ Scribed by J. C. Madelmont; M. F. Moreau; D. Parry; D. Godeneche; J. Duprat; G. Meyniel; J. Oiry; J. L. Imbach

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
364 KB
Volume
20
Category
Article
ISSN
0022-2135

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✦ Synopsis

For disposition and metabolic study CNCC was labelled by 35S, I4C, 3H on three positions :

on the two sulfur atom of the cystamine group on the urea carbonyl on the position 1 of the 2 chloro ethyl group.

RE SLIME

Dans le but de r6aliser des etudes de disposition et de 3 metabolisme le CNCC a ete marque par 35S, 14C, et H en trois positions :

sur les atomes de soufre du groupe cystamine sur le carbonyle ureique en position 1 du groupe chloro-2, Gthyle. Les chloro-2 alkyl nitrosourges (BCNU, CCNU, Me CCNU) et les chloro-2 Gthyl glycosyl nitrosourges (RFCNU, RPCNU, Chlorozotocine) constituent une classe importante d'oncostatiques dont le mBcanisme d'action "in viva" n'est pas toujours bien connu. La selection de ces composBs pour les essais cliniques passe par l'stude de leur

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