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Marquage par 14C et 3H du 4,4-dimethyl-1-(methylendioxy-3,4 phenyl)-1-pentene-3- ol ou stiripentol

✍ Scribed by J. C. Madelmont; J. M. Dupuy; M. Rapp; P. Labarre; J. C. Maurizis; F. Lepage; A. Veyre

Publisher
John Wiley and Sons
Year
1992
Tongue
French
Weight
264 KB
Volume
31
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

4,4‐dimethyl‐1‐(3‐4‐methylenedioxyphenyl)‐1‐pentene‐3‐ol or stiripentol was labelled by ^14^C and ^3^H.

^14^C labelling was performed on the carbone 1 of the pentene group via a four steps procedure after the carbonatation. The radiochemical yield calculated from the precursor (Ba^14^CO~3~) is 28%.

^3^H labelling was performed on the position 3 of the pentene chain by reduction of the corresponding cetone via NaBT~4~. The radiochemical yield calculated from the precursor (NaBT~4~) is 40%.

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