✦ LIBER ✦

Marquage par 14C ET 13C de la N acetyl O6 benzyl guanosine

✍ Scribed by J. C. Madelmont; C. Cussac; J. M. Dupuy; M. Rapp; P. Labarre; J. L. Chabard; J. C. Maurizis; J. Sauzieres; J. P. Baudry; D. Godeneche; A. Veyre

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 348 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580311009

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✦ Synopsis

Abstract

O~6~ Benzyl N acetyl guanosine a new inhibitor of O~6~ Alkyl Guanine transferase (O~6~AGT) was labelled by ^14^C and ^13^C on the benzyl methylen group in order to realize a pharmacokinetic study on nude mice grafted with human tumors.

The labelling yield calculated from the precursor (Ba ^14 or 13^CO~3~) is in the range of 15%.

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