The purpose of this study is to determine the functional role of P-glycoprotein (P-gp) in intestinal absorption of drugs and to quantitatively predict the in vivo absorption enhancement on P-gp inhibition. In situ single-pass rat ileum permeability and aqueous solubility were measured for a set of 1
Marked impact of P-glycoprotein on the absorption of TAK-427 in rats
β Scribed by Toshiyuki Takeuchi; Masami Nonaka; Sumie Yoshitomi; Tomoaki Higuchi; Takuya Ebihara; Yoshihiro Maeshiba; Masahiro Kawase; Satoru Asahi
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 162 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.609
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