Alendronate is a bisphosphonate that is secreted via a saturable pathway in rat kidney. This study is designed to discover if the rate-determining step in its net renal secretion is uptake into the renal tubule. The tissue uptake clearance of alendronate by the kidney, estimated from an integration
On the absorption of alendronate in rats
โ Scribed by Jiunn H. Lin; I-Wu Chen; Florencia A. Deluna
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 675 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0022-3549
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We studied the differences in pharmacokinetics and pharmacodynamics of the same dose of alendronate administered subcutaneously as intermittent bolus injection or continuous infusion in rats. Two rat models of bone disease were applied. Bone cancer was produced by intratibial inoculation of Walker c