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Profile of P-glycoprotein distribution in the rat and its possible influence on the salbutamol intestinal absorption process

✍ Scribed by Belén Valenzuela; Amparo Nácher; Purificación Ruiz-Carretero; Adela Martín-Villodre; Gracia López-Carballo; Domingo Barettino


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
163 KB
Volume
93
Category
Article
ISSN
0022-3549

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The hepatobiliary disposition of rhodamine 123 (RH-123) and its glucuronidated (RH-Glu) and deacylated (RH-110) metabolites were studied in an isolated perfused rat liver (IPRL) model in the presence and absence of P-glycoprotein (P-gp) and Mrp2 inhibitors. A single dose (180 mg) of RH-123 was added