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Mapping the Binding of the N-terminal Extracellular Tail of the CXCR4 Receptor to Stromal Cell-derived Factor-1α

✍ Scribed by Elliott K. Gozansky; John M. Louis; Michael Caffrey; G. Marius Clore


Book ID
116661809
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
540 KB
Volume
345
Category
Article
ISSN
0022-2836

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Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine produced by stromal cells that acts as a chemoattractant for human CD34 + progenitor cells. We investigated the expression of CXCR4, the receptor for SDF-1, on CD34 + cells from different hematopoietic sites and developmental stages. CXCR4 was