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Mapping of oxygen tension and cell distribution in a hollow-fiber bioreactor using magnetic resonance imaging

✍ Scribed by Shane N. O. Williams; Rainer M. Callies; Kevin M. Brindle

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 915 KB
Volume: 56
Category: Article
ISSN: 0006-3592
DOI: 10.1002/(sici)1097-0290(19971005)56:1<56::aid-bit6>3.0.co;2-u

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✦ Synopsis

We mapped the distribution of dissolved oxygen and mammalian cells in a hollow-fiber bioreactor (HFBR) using 19 F NMR T 1 relaxation time imaging measurements on an infused perfluorocarbon probe molecule and diffusion-weighted 1 H NMR imaging of water. This study shows how cell density influences dissolved oxygen concentration in the reactor and demonstrates that NMR can play an important role in defining the biochemical engineering parameters required for optimization of HFBR design and operation.

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