Allelic losses on chromosome arm 22q are frequently observed in human meningiomas and in carcinomas of the colon, ovary, and breast. Among 140 primary breast cancers we examined for loss of heterozygosity (LOH) at 16 polymorphic loci on the long arm of chromosome 22, 56 (40%) showed LOH for at least
Mapping of a target region of allelic loss to a 0.5-cm interval on chromosome 22q13 in human colorectal cancer
โ Scribed by Antoni Castells; Yasushi Ino; David N. Louis; Vijaya Ramesh; James F. Gusella; Anil K. Rustgi
- Book ID
- 118521937
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 178 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0016-5085
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As a first step toward understanding molecular mechanisms in human pancreatic carcinogenesis, we searched for the location of tumor suppressor genes by examining loss of heterozygosity (LOH) in 44 pancreatic cancer specimens. W e used 46 microsatellite markers that spanned all of the autosomes. Freq