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Mapping of a new target region of allelic loss to a 6-cM interval at 21q21 in primary breast cancers

✍ Scribed by Kenji Ohgaki; Aritoshi Iida; Fujio Kasumi; Goi Sakamoto; Masao Akimoto; Yusuke Nakamura; Mitsuru Emi

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 90 KB
Volume: 23
Category: Article
ISSN: 1045-2257
DOI: 10.1002/(sici)1098-2264(199811)23:3<244::aid-gcc6>3.0.co;2-1

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✦ Synopsis

A detailed analysis of loss of heterozygosity (LOH) in breast cancers was performed with 11 microsatellite markers on the long arm of chromosome 21. Among the 142 tumors examined, 44 (31%) showed LOH at one or more loci. Peak LOH frequency was observed on band 21q21. Deletion mapping identified a new commonly deleted region in a 6-cM interval of 21q21 between loci D21S1432 and D21S1437, and raised the possibility that one or more tumor suppressor genes associated with breast cancer may exist in this region. Comparison of these alterations with clinicopathological parameters revealed an association of LOH on 21q with loss of progesterone receptor (P ϭ 0.0013).

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