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Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor

✍ Scribed by Wang, Min; Kirk, Jeanie S; Venkataraman, Sujatha; Domann, Frederick E; Zhang, Hannah J; Schafer, Freya Q; Flanagan, Shawn W; Weydert, Christine J; Spitz, Douglas R; Buettner, Garry R; Oberley, Larry W


Book ID
110070024
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
416 KB
Volume
24
Category
Article
ISSN
0950-9232

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## Abstract In oxygenated cells, hypoxia‐inducible factor‐1 (HIF‐1) α subunits are rapidly degraded by a mechanism that involves ubiquitination by the von Hippel–Lindau tumor suppressor E3 ligase complex using 2‐oxoglutarate as a substrate. We examined the effect of 2‐oxoglutarate on the production