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Manganese induces cell swelling in cultured astrocytes

✍ Scribed by K.V. Rama Rao; P.V.B. Reddy; A.S. Hazell; M.D. Norenberg

Book ID: 116779828
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 163 KB
Volume: 28
Category: Article
ISSN: 0161-813X
DOI: 10.1016/j.neuro.2007.03.001

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## Abstract Manganese in excess is neurotoxic and causes CNS injury resembling that of Parkinson's disease. In brain, astrocytes predominantly take up and accumulate manganese and are thus vulnerable to its toxicity. Manganese was shown to induce cell swelling in cultured astrocytes, and oxidative/