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Manganese Decreases Glutamate Uptake in Cultured Astrocytes

✍ Scribed by Alan S. Hazell; Michael D. Norenberg


Book ID
110413311
Publisher
Springer
Year
1997
Tongue
English
Weight
549 KB
Volume
22
Category
Article
ISSN
0364-3190

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To test the hypothesis that clozapine-induced reduction of glutamate transporter-1 (GLT-1) expression is mediated by astrocytes, we studied the effects of clozapine on Glu transporters and Glu uptake in primary astrocyte cultures of the cerebral cortex. Astrocyte cultures treated for 48 h with cloza