Ovarian cancer is the fourth leading cause of cancer deaths in American women. About 10% of cases are thought to have a hereditary basis, and family history is the strongest known risk factor. In the past, prophylactic oophorectomy has been advocated for women with two or more affected first-degree
β¦ LIBER β¦
Managing hereditary ovarian cancer
β Scribed by M.J. Mourits; G.H. de Bock
- Book ID
- 116731993
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 154 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0378-5122
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There is increasing evidence that hereditary factors play a greater role in ovarian cancer than in any of the other common cancers of adulthood. This is attributable, to a large extent, to a high frequency of mutations in the BRCA1 or BRCA2 genes. In Poland, 3 common founder mutations in BRCA1 accou