Hereditary ovarian cancer
✍ Scribed by Jaime Prat; Adriana Ribé; Alberto Gallardo
- Book ID
- 116533989
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 386 KB
- Volume
- 36
- Category
- Article
- ISSN
- 1532-8392
No coin nor oath required. For personal study only.
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Ovarian cancer is the fourth leading cause of cancer deaths in American women. About 10% of cases are thought to have a hereditary basis, and family history is the strongest known risk factor. In the past, prophylactic oophorectomy has been advocated for women with two or more affected first-degree
There is increasing evidence that hereditary factors play a greater role in ovarian cancer than in any of the other common cancers of adulthood. This is attributable, to a large extent, to a high frequency of mutations in the BRCA1 or BRCA2 genes. In Poland, 3 common founder mutations in BRCA1 accou