Management of polyamine pools and the regulation of ornithine decarboxylase

✍ Scribed by Rowland H. Davis

• Publisher: John Wiley and Sons
• Year: 1990
• Tongue: English
• Weight: 529 KB
• Volume: 44
• Category: Article
• ISSN: 0730-2312
• DOI: 10.1002/jcb.240440402

✦ Synopsis

The management of polyamine synthesis and polyamine pools differs fundamentally from that of most other small molecular-weight endproducts. The polyamines are vital to growth and important cellular functions, but they are toxic in excess. I argue here that their multivaient cationic character, leading to binding to cell constituents, precludes fluent feedback inhibition of synthesis. This has led to the development of elaborate alternative regulatoy mechanisms controlling ornithine decarboxylase, the key initial enzyme of the pathway. Poorly regulated polyamine synthesis and the toxicity of polyamines impose upon cells a need to control uptake and to dispose of excess polyamines. Recent data on polyamine transport suggest unorthodox mechanisms of accomplishing these functions.