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Malignant Transformation of Normal Human Keratinocytes by SV40 Virus

โœ Scribed by JOHN J. WILLE

Book ID
119862846
Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
726 KB
Volume
567
Category
Article
ISSN
0890-6564

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The production of fibronectin, laminin and glycosaminoglycans (GAGs) has been investigated in normal and SV40-transformed human epidermal keratinocytes. Normal keratinocytes pruduced small amounts of laminln and fibronectin and three classes of GAGs; hyaluronic acid, heparan sulphate and chondroitin

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## Abstract Fluorescein dye microinjection was used to demonstrate changes in communication between human epidermal keratinocytes grown in vitro after infection by the oncogenic virus, SV40. Whereas keratinocytes are normally fully coupled to each other, dye spread becomes progressively restricted