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Patterns of cell communication and differentiation in SV40 transformed human keratinocytes

✍ Scribed by Mark Steinberg; Vittorio Defendi

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 778 KB
Volume: 109
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041090117

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Fluorescein dye microinjection was used to demonstrate changes in communication between human epidermal keratinocytes grown in vitro after infection by the oncogenic virus, SV40. Whereas keratinocytes are normally fully coupled to each other, dye spread becomes progressively restricted to small cell subpopulations after infection, although dye coupling is increased when the infected cells attain high densities. Reduction or enhancement of dye coupling is correlated with similar changes in the extent of cytochemical differentiation and cornified envelope formation.

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