Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget disease and demonstrate that the Paget disease
Malignant transformation in paget disease of bone
โ Scribed by Alexander Hadjipavlou; Philip Lander; Herbert Srolovitz; I. Paul Enker
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 765 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0008-543X
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## Abstract The karyotypes of 14 patients with Paget's disease of bone were studied. The patients were recruited from our bone metabolism clinic where they received specific therapy for their skeletal disease. Eight of the 14 patients had chromosomal translocations localized to the D and G groups.
Although the measurement of total alkaline phosphatase activity in serum is a valid index to 8ssess the activity of Paget's disease of bone and to monitor treatment efficacy, this marker may lack sensitivity in some cases. Among the various markers of bone formation and resorption that have been dev