Bisphosphonate resistance in Paget's disease of bone
β Scribed by Fred Joshua; Martin Epstein; Gabor Major
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 49 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0004-3591
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π SIMILAR VOLUMES
Paget disease of the bone is a common skeletal disorder. Recently, a gene for Paget disease was localized to 18q with subsequent evidence for linkage heterogeneity. We report the identification and clinical characterization of a large pedigree of Paget disease and demonstrate that the Paget disease
## Abstract Etidronate used in recommended doses (usually 5 mg/kg/day for 6 months) produces symptomatic improvement in approximately 60% of patients. The serum alkaline phosphatase and urinary hydroxyproline are reduced to about 50% of initial values. A sustained remission occurs in many patients