Arthritis in paget's disease of bone
β Scribed by Roy D. Altman
- Publisher
- American Society for Bone and Mineral Research
- Year
- 1999
- Tongue
- English
- Weight
- 365 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0884-0431
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π SIMILAR VOLUMES
## Abstract The karyotypes of 14 patients with Paget's disease of bone were studied. The patients were recruited from our bone metabolism clinic where they received specific therapy for their skeletal disease. Eight of the 14 patients had chromosomal translocations localized to the D and G groups.
Although the measurement of total alkaline phosphatase activity in serum is a valid index to 8ssess the activity of Paget's disease of bone and to monitor treatment efficacy, this marker may lack sensitivity in some cases. Among the various markers of bone formation and resorption that have been dev
## Abstract Etidronate used in recommended doses (usually 5 mg/kg/day for 6 months) produces symptomatic improvement in approximately 60% of patients. The serum alkaline phosphatase and urinary hydroxyproline are reduced to about 50% of initial values. A sustained remission occurs in many patients