Malignant hyperthermia in the pig: Aetiology, therapy and implications
β Scribed by Mcloughlin, J. V.
- Publisher
- Springer-Verlag
- Year
- 1977
- Weight
- 376 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0378-4312
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Malignant hyperthermia (MH) is an autosomal dominant disorder characterized by abnormal calcium homeostasis in skeletal muscle in response to triggering agents. Today, genetic investigations on ryanodine receptor type 1 (RYR1) gene and alpha1 subunit of the dihydropyridine receptor (DHPR) (CACNA1S)
## Abstract A 14βyearβold boy, an only child, with the phenotypical dysmorphic features of the KingβDenborough Syndrome developed a severe hyperthermic episode during anesthesia which responded to the administration of sodium dantrolene. As adequate metabolic studies were not available at the time