Malignant hyperthermia (MH) is an autosomal dominant disorder characterized by abnormal calcium homeostasis in skeletal muscle in response to triggering agents. Today, genetic investigations on ryanodine receptor type 1 (RYR1) gene and alpha1 subunit of the dihydropyridine receptor (DHPR) (CACNA1S)
Electrodiagnostic tests in the detection of malignant hyperthermia
β Scribed by Dr. Gloria D. Eng; Matthew J. Becker; Sheila M. Muldoon
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 618 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0148-639X
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Malignant hyperthermia (MH) is a potentially lethal pharmacogenetic disease, triggered by inhalative anesthetics or depolarizing muscle relaxants in genetically predisposed individuals. Linkage analysis have revealed MH to be a heterogenetic disease with about 50% of MH families linked to the locus
We studied the electrical properties of intact muscle fibers from normal and malignant hyperthermia-susceptible (MHS) pigs. Resting membrane potentials, action potentials, and current-voltage relationships were measured with and without the presence of halothane. There were no changes in the resting