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Making CENs of Mammalian Artificial Chromosomes

โœ Scribed by Peter E. Warburton


Book ID
115639592
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
88 KB
Volume
68
Category
Article
ISSN
1096-7192

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A mammalian artificial chromosome (MAC) may be assembled through the juxtapposition of three kinds of DNA elements: a centromere, several DNA replication origins, and two telomeric repeats. The resulting structure should be able to carry and express one or more selected genes (transgenes), introduce