𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses

✍ Scribed by Kenneth W Turteltaub; Karen H Dingley; Kellie D Curtis; Michael A Malfatti; Robert J Turesky; R Colin Garner; James S Felton; Nicholas P Lang

Book ID
117469481
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
170 KB
Volume
143
Category
Article
ISSN
0304-3835

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Comparison of DNA-adduct and tissue-avai
Comparison of DNA-adduct and tissue-available dose levels of MeIQx in human and rodent colon following administration of a very low dose
✍ Robert J. Mauthe; Karen H. Dingley; Steven H. Leveson; Stewart P.H.T. Freeman; R πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 French βš– 96 KB πŸ‘ 1 views

2-14 C]2-amino-3,8-dimethylimidazo[4,5-f ]quinoxaline (MeIQx) was administered orally (304 ng/kg body-weight dose based upon an average 70-kg-body-weight subject) to 5 human colon-cancer patients (58 to 84 years old), as well as to F344 rats and B 6 C 3 F 1 mice. Colon tissue was collected from the

Effects of polyunsaturated fatty acids o
Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells
✍ H.J.J. Moonen; Y.E.M. Dommels; M. van Zwam; M.H.M. van Herwijnen; J.C.S. Kleinja πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 185 KB

## Abstract Dietary heterocyclic aromatic amines (HCA) and polyunsaturated fatty acids (PUFA) are both believed to play a role in colon carcinogenesis, and are both substrate for the enzyme cyclooxygenase (COX). In HCA‐7 cells, highly expressing isoform COX‐2, we investigated the effects of PUFA on