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Macrolactamization versus Macrolactonization: Total Synthesis of FK228, the Depsipeptide Histone Deacetylase Inhibitor†

✍ Scribed by Wen, Shijun; Packham, Graham; Ganesan, A.

Book ID
115513302
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
257 KB
Volume
73
Category
Article
ISSN
0022-3263

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## Abstract Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly silenced genes. In this study, we conducted a detailed analysis of anti‐leukemic effects of an HDAC inhibitor (HDI), depsipeptide (FK228), using myeloid leukemia cel