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Romidepsin (FK228), a potent histone deacetylase inhibitor, induces apoptosis through the generation of hydrogen peroxide

✍ Scribed by Hideki Mizutani; Yusuke Hiraku; Saeko Tada-Oikawa; Mariko Murata; Kenji Ikemura; Takuya Iwamoto; Yoshiyuki Kagawa; Masahiro Okuda; Shosuke Kawanishi

Book ID
108586802
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
301 KB
Volume
101
Category
Article
ISSN
1347-9032

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## Abstract Inhibition of histone deacetylase (HDAC) is a novel strategy for the treatment of leukemias via restoration of aberrantly silenced genes. In this study, we conducted a detailed analysis of anti‐leukemic effects of an HDAC inhibitor (HDI), depsipeptide (FK228), using myeloid leukemia cel