Macrocyclization on solid support using Heck reaction
β Scribed by Kenichi Akaji; Yoshiaki Kiso
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 242 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Solid phase intramolecularHeck couplingallows the syothesisof 2-oxindoles. Additional diversityis introducedinfo the moleculeby reductiveatkylationprior to the Heck cyclisationarrdatso by conjugateadditionof a varietyof nucleophilesontothe cyctisedproductprior to cleavage. 01997 Elsevier ScienceLtd.
## Abstract We have revisited the intramolecular Heck reaction and investigated the microwaveβassisted macrocyclization on preformed peptides using a model series of ringβvarying peptides acryloylβGlyβ[Gly]~n~βPhe(4βI)NHR; n ο£Ύ 0β4. The method was applied to both solution and solid supported cycliza
The Gewald reaction was performed on solid support. This reaction combines a ketone or aldehyde, an activated nitrile, and sulfur in the presence of a suitable amine base to make tri-and tetrasubstituted thiophenes. After optimizing conditions for maximum yield and purity, the scope of the reaction
## Abstract A polymerβsupported macrocyclic Schiff base palladium complex has been synthesized. In the Heck reaction of aryl iodides and bromides with ethyl acrylate or styrene, the complex has been proved to give the corresponding products in good to excellent yields. The reaction proceeded smooth