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M2033 Blockade of TNF Alpha Reduces Pancreatic Tumor Growth and Metastasis in a Xenotransplantation Model

✍ Scribed by Egberts, Jan H.; Schniewind, Bodo; Schafmayer, Clemens; Noack, Andreas; Tepel, Juergen; Faendrich, Fred; Kalthoff, Holger; Trauzold, Anja

Book ID: 122377718
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 80 KB
Volume: 134
Category: Article
ISSN: 0016-5085
DOI: 10.1016/S0016-5085(08)62126-5

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Anti-tumor effects of TNF in animal models are well documented. Therapeutic use of TNF, however, is hampered by its toxicity. In rats a single intravenous (i.v.) injection of 40 pg/kg is lethal. When given by continuous i.v. infusion, much higher doses are well tolerated. To compare the therapeutic