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Lysine functionalised amyloid fibrils: the design and assembly of a TTR1-based peptide

✍ Scribed by Bongiovanni, Marie N.; Caruso, Frank; Gras, Sally L.


Book ID
120933041
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
785 KB
Volume
9
Category
Article
ISSN
1744-683X

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## Abstract Aβ~16–22~ (Ac‐KLVFFAE‐NH~2~) is one of the shortest amyloid fibril‐forming sequences identified in β‐amyloid peptide. At neutral pH, the peptide forms fibrils in the concentration range of 0.2–2.0 mM after ≥ 10 days of incubation. Structures of the fibrils proposed based on solid‐state