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Formation and seeding of amyloid fibrils from wild-type hen lysozyme and a peptide fragment from the β-domain

✍ Scribed by Mark R.H Krebs; Deborah K Wilkins; Evonne W Chung; Maureen C Pitkeathly; Aaron K Chamberlain; Jesus Zurdo; Carol V Robinson; Christopher M Dobson


Book ID
115630329
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
394 KB
Volume
300
Category
Article
ISSN
0022-2836

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✍ Nitin Chaudhary; Ramakrishnan Nagaraj 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 364 KB

## Abstract Aβ~16–22~ (Ac‐KLVFFAE‐NH~2~) is one of the shortest amyloid fibril‐forming sequences identified in β‐amyloid peptide. At neutral pH, the peptide forms fibrils in the concentration range of 0.2–2.0 mM after ≥ 10 days of incubation. Structures of the fibrils proposed based on solid‐state