Impact on the replacement of Phe by Trp
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Nitin Chaudhary; Ramakrishnan Nagaraj
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Article
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2010
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John Wiley and Sons
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English
⚖ 364 KB
## Abstract Aβ~16–22~ (Ac‐KLVFFAE‐NH~2~) is one of the shortest amyloid fibril‐forming sequences identified in β‐amyloid peptide. At neutral pH, the peptide forms fibrils in the concentration range of 0.2–2.0 mM after ≥ 10 days of incubation. Structures of the fibrils proposed based on solid‐state