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Lung tumour incidence in mice treated with hydrazine sulphate

✍ Scribed by S. V. Bhide; R. A. D'souza; Kamal J. Ranadive; M. M. Sawai

Publisher: John Wiley and Sons
Year: 1976
Tongue: French
Weight: 603 KB
Volume: 18
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910180418

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Lung tumour incidence in mice fed with hydrazine sulphate (1.1 mg/day/mouse) was studied in male and female mice of Swiss, Strong “A” and F~1~ cross of ICRC (female) × C3H (Jax) (male), as well as in C17 males. Swiss strain mice showed 100% lung adenocarcinomas. None of the treated mice of different strains had liver tumours. Hydrazine sulphate also induced adenocarcinomas of lung in Strong “A” and F~1~ cross of ICRC females × C3H (Jax) males but it produced lymphomas of lung in C17 strain. Female mice of Swiss strain and F~1~ hybrids showed greater susceptibility to hydrazine sulphate than the males. It was interesting to observe that protein and vitamin B deficiency in the diet shortened the tumour induction period in Swiss strain mice.

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