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In vivo mutagenesis in the lungs of gpt-delta transgenic mice treated intratracheally with 1,6-dinitropyrene

✍ Scribed by Akiko H. Hashimoto; Kimiko Amanuma; Kyoko Hiyoshi; Hirohisa Takano; Ken-ichi Masumura; Takehiko Nohmi; Yasunobu Aoki


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
171 KB
Volume
47
Category
Article
ISSN
0893-6692

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## Abstract In order to cast light on carcinogen‐specific molecular mechanisms underlying experimental hepatocarcinogenesis in rats, in vivo mutagenicity and mutation spectra of known genotoxic rat hepatocarcinogens __N__‐nitrosopyrrolidine (NPYR), and 2‐amino‐3‐methylimidazo[4,5‐__f__]quinoline (I