The incidence of lung tumours in C57BL mice exposed to cigarette smoke:Air mixtures for prolonged periods

✍ Scribed by R. J. C. Harris; G. Negroni; Susan Ludgate; C. R. Pick; F. C. Chesterman; B. J. Maidment

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: French
• Weight: 415 KB
• Volume: 14
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910140116

✦ Synopsis

Abstract

C57BI mice, allowed to breathe a cigarette smoke:air mixture for short periods and at frequent intervals throughout their lives, develop a higher incidence of lung cancers, adenomas and carcinomas, than untreated control animals. Smoke from cigarettes made from a flue‐cured tobacco (T2) was more toxic and elicited cancers more quickly than that from cigarettes made from air‐dried tobacco (T3) from the same crop. Filtered smoke :air from T2 and unfiltered smoke gave similar yields of lung tumours.