## Abstract To investigate the frequency of mutations in the LeucineβRich Repeat Kinase 2 gene (__LRRK2__) in a sample of Austrian Parkinson's disease (PD) patients, we sequenced the complete coding region in 16 patients with autosomal dominant PD. Furthermore, we sequenced exons 31, 35, and 41 add
LRRK2 mutations in a clinic-based cohort of Parkinson's disease
β Scribed by S. Scholz; R. J. Mandel; H. H. Fernandez; K. D. Foote; R. L. Rodriguez; E. Barton; S. Munson; A. Singleton; M. S. Okun
- Book ID
- 111064793
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 71 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1351-5101
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## Abstract Mutations in the leucineβrich repeat kinase 2 (__LRRK2__) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycineβtoβserine amino acid substitution at cod
## Abstract The G2019S mutation in the __LRRK2__ gene is reportedly a common cause of familial Parkinson's disease (PD) and may also have a significant role in nonfamilial PD. The objective of this study was to assess mutation carrier frequency in PD patients from movement disorder clinics in the U