✦ LIBER ✦

Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease

✍ Scribed by Hon-Chung Fung; Chiung-Mei Chen; John Hardy; Dena Hernandez; Andrew Singleton; Yih-Ru Wu

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 46 KB
Volume: 21
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.20814

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✦ Synopsis

Abstract

Mutations in the leucine‐rich repeat kinase 2 (LRRK2) gene have been shown to cause autosomal dominant and sporadic Parkinson's disease (PD). We report here the frequency of a common heterozygous mutation, 2877510G>A, which produces a glycine‐to‐serine amino acid substitution at codon 2019 in idiopathic Taiwanese PD. The extreme rarity of the G2019S mutation in our population suggests the occurrence of this mutation resulted from a common European founder. © 2006 Movement Disorder Society

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